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báo cáo khoa học: " Developmental origins of health and disease: reducing the burden of chronic disease in the next generation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Developmental origins of health and disease: reducing the burden of chronic disease in the next generation | Gluckman et al. Genome Medicine 2010 2 14 http genomemedicine.eom content 2 2 14 w Genome Medicine COMMENTARY L__ Developmental origins of health and disease reducing the burden of chronic disease in the next generation Peter D Gluckman -2 Mark A Hanson3 and Murray D Mitchell 4 Abstract Despite a wealth of underpinning experimental support there has been considerable resistance to the concept that environmental factors acting early in life usually in fetal life have profound effects on vulnerability to disease later in life often in adulthood. This has resulted in an unwillingness among public health decision makers to implement relatively simple approaches based upon an understanding of developmental plasticity and intergenerational influences to reducing the burden of disease particularly in low socioeconomic groups. The concept of developmental origins of health and disease is predicated upon the assumption that environmental factors acting early in life usually in fetal life have profound effects on vulnerability to disease later in life often in adulthood. The range of experimental clinical and epidemiological data linking conditions in early life to later health is now overwhelming 1 . Initially the focus was on a small fraction of children -those who were born small - but it is now clear that the environment impacts on the development of every child 2 . Observations and experimental approaches have generally considered nutritional changes or classically alterations in glucocorticosteroid exposure reflecting the critical maturational events linked to such events. Indeed the placenta is in a critical position to cause or modify such challenges by altering nutritional transport functions or the pattern and nature of endocrine signals impacting the fetus. Nor does the story end at birth because epigenetic development can be influenced by how the infant is fed Correspondence murray.mitchell@uq.edu.au 4UQ Centre for Clinical Research Building 71 198 Royal