tailieunhanh - Báo cáo khoa hoc:" Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats | Journal of Negative Results in BioMedicine BioMed Central Research Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats Jian Xu 1 Huai C Yan 1 Bo Yang2 Lu S Tong3 Yu X Zou1 and Ying Tian1 Open Access Address 1Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute for Pediatric Research Shanghai Key Laboratory of Children s Environmental Health No. 1665 Kong Jiang Road Shanghai 200092 PR China 2Shanghai Children s Medical Center Shanghai Jiao Tong University School of Medicine No. 1678 Dong Fang Road Shanghai 200127 PR China and institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove Brisbane Queensland 4059 Australia Email JianXu Huai CYan -Yanch@ BoYang-yangbosh@ Lu S Tong - Yu X Zou - zouxiangyu1978@ Ying Tian - tianmiejp@ Corresponding authors Published 20 April 2009 Received 9 December 2008 Journal of Negative Results in BioMedicine 2009 8 5 doi l 477-5751-8-5 Accepted 20 April 2009 This article is available from http content 8 1 5 2009 Xu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A complete explanation of the mechanisms by which Pb2 exerts toxic effects on developmental central nervous system remains unknown. Glutamate is critical to the developing brain through various subtypes of ionotropic or metabotropic glutamate receptors mGluRs . Ionotropic N-methyl-D-aspartate receptors have been considered as a principal target in lead-induced neurotoxicity. The relationship between mGluR3 mGluR7 and synaptic plasticity had been verified by many recent studies. The .

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