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Báo cáo y học: "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is ne"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new? | Available online http arthritis-research.eom content 11 3 231 Review Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis what is new Yvonne Vercoulen1 Nienke H van Teijlingen1 Ismé M de Kleer1 Sylvia Kamphuis1 Salvatore Albani2 3 and Berent J Prakken1 2 1 Department of Pediatric Immunology Wilhelmina Children s hospital UMCU Lundlaan 6 3584 EA Utrecht The Netherlands 2Eureka Institute for Translational Medicine Viale Teracati 50a 96100 Siracusa Italy 3The University of Arizona College of Medicine 1501 N. Campbell Avenue PO BOX 245093 Tucson AZ USA Corresponding author Berent Prakken bprakken@umcutrecht.nl Published 19 May 2009 This article is online at http arthritis-research.com content 11 3 231 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 231 doi 10.1186 ar2674 Abstract Juvenile idiopathic arthritis JIA is a disease characterized by chronic joint inflammation caused by a deregulated immune response. In patients with JIA heat shock proteins HSPs are highly expressed in the synovial lining tissues of inflamed joints. HSPs are endogenous proteins that are expressed upon cellular stress and are able to modulate immune responses. In this review we concentrate on the role of HSPs especially HSP60 in modulating immune responses in both experimental and human arthritis with a focus on JIA. We will mainly discuss the tolerogenic immune responses induced by HSPs which could have a beneficial effect in JIA. Overall we will discuss the immune modulatory capacity of HSPs and the underlying mechanisms of HSP60-mediated immune regulation in JIA and how this can be translated into therapy. Introduction Juvenile idiopathic arthritis JIA is an autoimmune disease of unknown cause characterized by a deregulated immune response in synovial lining tissues of the joints leading to chronic arthritis in children. According to the latest classification provided by the International League of Associations for Rheumatology seven categories of JIA can be .

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