tailieunhanh - Báo cáo y học: " Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes. | Available online http content 10 2 R41 Open Access Research article Extracellular heat shock protein 70 inhibits tumour necrosis factor-a induced proinflammatory mediator production in fibroblast-like synoviocytes Xinjing Luo1 2 Xiaoxia Zuo3 Yaou Zhou3 Bing Zhang1 Yongzhong Shi1 Meidong Liu1 Kangkai Wang1 D Randy McMillian4 and Xianzhong Xiao1 Department of Pathophysiology Xiangya School of Medicine Central South University Xiangya Road Changsha Hunan 410008 China department of Laboratory Medicine Medical College of Taizhou University Shifu Road Taizhou Zhejiang 318000 China department of Rheumatology and Clinical Immunology Xiangya Hospital Central South University Xiangya Road Changsha Hunan 410008 China department of Pediatrics University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas Texas 75390-9063 USA Corresponding author Xiaoxia Zuo susanzuo@ Xiao xianzhongxiao@ Received 28 Dec 2007 Revisions requested 6 Feb 2008 Revisions received 27 Feb 2008 Accepted 14 Apr 2008 Published 14 Apr 2008 Arthritis Research Therapy 2008 10 R41 doi ar2399 This article is online at http content 10 2 R41 2008 Luo et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction It was recently suggested that heat shock protein HSP 70 an intracellular protein is a potential mediator of inflammatory disease when it is released into the extracellular compartment. Although elevated HSP70 levels have been identified in rheumatoid arthritis RA synovial tissues and RA synovial fluid compared with patients with osteoarthritis and healthy individuals it remains unclear what role extracellular HSP70 plays in the pathogenesis of RA. This .

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