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Báo cáo y học: "Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen specie"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species. | Available online http arthritis-research.eom content 9 2 R29 Research article Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species Anna-Marie Fairhurst1 Paul K Wallace2 Ali SM Jawad3 and Nicolas J Goulding1 1William Harvey Research Institute Barts and the London Queen Mary s School of Medicine and Dentistry Charterhouse Square London EC1M 6BQ UK _ 2Flow Cytometry Center Roswell Park Cancer Institute Elm and Carlton Streets Buffalo NY 14263 USA 3Department of Rheumatology Barts and the London NHS Trust Bancroft Road Mile End London E1 4DG UK Corresponding author Nicolas J Goulding n.j.goulding@qmul.ac.uk Received 11 Dec 2006 Revisions requested 22 Jan 2007 Revisions received 15 Feb 2007 Accepted 13 Mar 2007 Published 13 Mar 2007 Arthritis Research Therapy 2007 9 R29 doi 10.1186 ar2144 This article is online at http arthritis-research.com content 9 2 R29 2007 Fairhurst et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Significant levels of circulating immune complexes ICs containing rheumatoid factors and immunoglobulin G in peripheral blood are a characteristic feature of rheumatoid arthritis RA . ICs interact through Fcy receptors FcyR to activate phagocytes in numerous inflammatory processes. The high concentration of neutrophils in synovial fluid during active phases of the disease together with their destructive capacity pose important questions as to their role in the pathogenesis of RA. Functional defects in RA or control peripheral blood neutrophil FcyRs were examined with a specific FcyR-mediated reactive oxygen species ROS assay. Heterologous cross linking of FcyRIIa and FcyRIIIb on neutrophils resulted in a .