tailieunhanh - Báo cáo y học: "Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. | Available online http content 11 3 R84 Research article Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor M Margarida Souto-Carneiro1 Vijayabhanu Mahadevan2 Kazuki Takada3 Ruth Fritsch-Stork4 Toshihiro Nanki3 Margaret Brown5 Thomas A Fleisher5 Mildred Wilson2 Raphaela Goldbach-Mansky2 and Peter E Lipsky2 1Centro de Neurociências e Biologia Celular Department of Zoology University of Coimbra 3004-517 Coimbra Portugal 2National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH 9000 Rockville Pike Bethesda MD 20892 USA 3Department of Medicine and Rheumatology Graduate School Tokyo Medical and Dental University 1 -5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan 4Department of Rheumatology UMC Utrecht Heidelberglaan 100 3584 CX Utrecht The Netherlands 5Department of Laboratory Medicine Warren Magnuson Center NIH 9000 Rockville Pike Bethesda MD 20892 USA Contributed equally Corresponding author Peter E Lipsky peterlipsky@ Received 23 Jan 2009 Revisions requested 6 Mar 2009 Revisions received 20 Apr 2009 Accepted 5 Jun 2009 Published 5 Jun 2009 Arthritis Research Therapy 2009 11 R84 doi ar2718 This article is online at http content 11 3 R84 2009 Souto-Carneiro et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Disturbances in peripheral blood memory B cell subpopulations have been observed in various autoimmune diseases but have not been fully delineated in rheumatoid arthritis RA . Additionally the possible role of tumour necrosis factor TNF in regulating changes in specific peripheral blood memory B cell subsets in RA is .