tailieunhanh - Báo cáo y học: "The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis. | Available online http content 7 6 R1189 Research article The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis Manuela Rossol1 Sylke Kaltenhauser1 Roger Scholz2 Holm Hantzschel1 Sunna Hauschildt3 and Ulf Wagner1 Department of Medicine IV University of Leipzig Leipzig Germany 2Department of Orthopedics University of Leipzig Leipzig Germany 3Department of Immunobiology Institute of Zoology University of Leipzig Leipzig Germany Corresponding author Ulf Wagner wagu@ Received 3 Mar 2005 Revisions requested 1 7 Mar 2005 Revisions received 16 Jul 2005 Accepted 20 Jul 2005 Published 17 Aug 2005 Arthritis Research Therapy 2005 7 R1189-R1199 DOI ar1804 This article is online at http content 7 6 R1189 2005 Rossol et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Stimulation of monocytes macrophages after cell contact with preactivated T cells has been suggested to contribute to the excessive TNF-a production in rheumatoid arthritis RA . In this study T cell-contact-dependent TNF-a production by peripheral-blood monocytes in vitro was investigated and found to be significantly lower in treated and untreated patients with RA than in healthy controls. This suppression was not due to a general deficiency of monocytes to respond because responses to lipopolysaccharide were comparable in patients and controls. In agreement with the pivotal role of TNF-a in RA T cell-dependent induction of TNF-a in synovial macrophages was fivefold to tenfold higher than in peripheral-blood monocytes from either patients or controls. The decreased response of .