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Báo cáo y học: "Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs. | Available online http arthritis-research.eom content 8 2 R42 Research article Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs Patricia Lopez1 Jesus Gomez2 Lourdes Mozo2 Carmen Gutierrez1 2 and Ana Suárez1 Department of Functional Biology Area of Immunology University of Oviedo. Spain 2Department of Immunology Hospital Universitario Central de Asturias Oviedo. Spain Corresponding author Ana Suárez anasua@uniovi.es Received 2 Nov 2005 Revisions requested 6 Dec 2005 Revisions received 20 Dec 2005 Accepted 11 Jan 2006 Published 13 Feb 2006 Arthritis Research Therapy 2006 8 R42 doi 10.1186 ar1 897 This article is online at http arthritis-research.com content 8 2 R42 2006 Lopez et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Antimalarial agents have been widely used as disease-modifying antirheumatic drugs in the treatment of systemic lupus erythematosus SLE and other rheumatological diseases although their mechanism of action has not yet been fully defined. It is known however that effective response to treatment is variable among patients. Thus the identification of genetic predictors of treatment response would provide valuable information for therapeutic intervention. The aim of the present study was to analyze the effect of antimalarial treatment on tumor necrosis factor TNF a serum levels and evaluate the possible influence of TNFa and IL-10 functional genetic polymorphisms on the response to antimalarial drugs. To this end TNFa serum levels were quantified in 171 SLE patients and 215 healthy controls by ELISA techniques and polymorphisms at positions -1 082 and -308 of the IL-10 and TNFa gene promoterswere determined by PCR amplification .