tailieunhanh - Báo cáo y học: "Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synoviu"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium. | Abdollahi-Roodsaz et al. Arthritis Research Therapy 2011 13 105 http content 13 2 105 EDITORIAL Trapped in a vicious loop Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium Shahla Abdollahi-Roodsaz Fons AJ van de Loo and Wim B van den Berg See related research by Nic An Ultaigh etal. http content 13 1 R33 Abstract Synovial tissue of patients with rheumatoid arthritis RA spontaneously produces several cytokines of which a fundamental role in joint inflammation and destruction has been established. However the factors sustaining this phenomenon remain poorly understood. In a recent report blockade of Toll-like receptor 2 TLR2 was found to inhibit the spontaneous release of inflammatory cytokines by intact RA synovial explant cultures. Adding to the recent evidence implicating other TLRs in particular TLR4 this observation highlights the potential of TLRs as therapeutic targets to suppress the local production of multiple cytokines and to control the chronic inflammatory loop in RA. Spontaneous production of inflammatory cytokines along with tissue-destructive enzymes is one of the unique characteristics of rheumatoid arthritis RA synovial tissue. The discovery of this phenomenon by Brennan and colleagues in 1989 has led to the understanding of the central role of tumor necrosis factor-alpha TNFa and its position upstream of interleukin-1 IL-1 and IL-6 in RA. As major mediators of joint inflammation and destruction these cytokines have become targets of novel therapeutics in recent years however the factors driving their production remain largely unknown. In the previous issue of Arthritis Research Therapy Nic An Ultaigh and colleagues 1 reported that Toll-like receptor 2 TLR2 mediates spontaneous cytokine release from RA ex vivo synovial explant cultures. Correspondence Rheumatology Research and Advanced Therapeutics Department of Rheumatology Radboud .