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Báo cáo y học: "Time courses of improvement and symptom remission in children treated with atomoxetine for attention-deficit/hyperactivity disorder: analysis of Canadian open-label studies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Time courses of improvement and symptom remission in children treated with atomoxetine for attention-deficit/hyperactivity disorder: analysis of Canadian open-label studies. | Dickson et al. Child and Adolescent Psychiatry and Mental Health 2011 5 14 http www.capmh.eom content 5 1 14 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH RESEARCH Open Access Time courses of improvement and symptom remission in children treated with atomoxetine for attention-deficit hyperactivity disorder analysis of Canadian open-label studies Ruth A Dickson1 Ellen Maki2 Christopher Gibbins3 Stephen W Gutkin4 Atilla Turgay5 and Margaret D Weiss3 Abstract Background The relatively short durations of the initial pivotal randomized placebo-controlled trials involving atomoxetine HCl for the treatment of attention-deficit hyperactivity disorder ADHD provided limited insight into the time courses of ADHD core symptom responses to this nonstimulant selective norepinephrine reuptake inhibitor. The aim of this analysis was to evaluate time courses of treatment responses or remission as assessed by attainment of prespecified scores on the ADHD Rating Scale-IV-Parent Version Investigator Administered and Scored ADHDRS-IV-PI and the Clinical Global Impressions-ADHD-Severity CGI-ADHD-S scales during up to 1 year of atomoxetine treatment in children with ADHD. Methods Using pooled data from three Canadian open-label studies involving 338 children ages 6-11 years with ADHD who were treated with atomoxetine for 3 6 and 12 months and survival analysis methods for interval-censored data we estimated the time to 1 improvement and robust improvement defined by 25 and 40 reductions from baseline ADHDRS-IV-PI total scores respectively and 2 remission using two definitions a final score of ADHDRS-IV-PI 18 or a final score of CGI-ADHD-S 2. Results The median time to improvement was 3.7 weeks 1 month but remission of symptoms did not occur until a median of 14.3 weeks 3.5 months using the most stringent CGI-ADHD-S threshold. Probabilities of robust improvement were 47 at or before 4 weeks of treatment 76 at 12 weeks 85 at 26 weeks and 96 at 52 weeks. Probabilities of remission at these .