tailieunhanh - Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block. | Int. J. Med. Sci. 2008 5 333 International Journal of Medical Sciences ISSN 1449-1907 2008 5 6 333-340 Ivyspring International Publisher. All rights reserved Research Paper Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block Gunnar Plehn M Julia Vormbrock Thomas Butz Martin Christ Hans-Joachim Trappe and Axel Meissner Department of Cardiology and Angiology Marienhospital Herne University of Bochum Germany H Correspondence to Gunnar Plehn MD Department of Cardiology and Angiology Marienhospital Herne University of Bochum Holkeskampring 40 44625 Herne Germany. Tel. 0049 -2323-4995617 Fax 0049 -2323-499301 Email Received Accepted Published Background In patients with idiopathic dilated cardiomyopathy IDCM a prolongation of left ventricular LV systole at the expense of diastolic time was demonstrated. Our study was aimed to evaluate the effect of exercise on heart rate corrected diastolic time in controls IDCM with and without LBBB and patients with LBBB and normal LV function. Methods 47 patients with IDCM 30 without LBBB and 17 with LBBB as well as 11 with isolated LBBB were studied during exercise using a combined hemodynamic-radionuclide angiographic approach. The phases of the cardiac cycle were derived with high temporal resolution from the ventricular time-activity curve. The loss of diastolic time per beat LDT was quantified using a regression equation obtained from a control group n 24 . Results A significant LDT was demonstrated at rest and during peak exercise in IDCM patients with LBBB 32 and 30 ms p . In IDCM patients with normal activation LDT was unaffected at baseline but elevated during peak exercise. This response was paralleled by an increase in interventricular mechanical dyssynchrony. Conclusion During exercise an abnormal shortening of LV .