tailieunhanh - Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/ B4 on nicotine dependence

The CHRNA5/A3/B4 gene locus is associated with nicotine dependence and other smoking related disorders. While the non-synonymous CHRNA5 variant rs16969968 appears to be the main risk factor, linkage disequilibrium (LD) bins in the gene cluster carry frequent variants that regulate expression. |

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