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Báo cáo y học: " Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity | Retrovirology BioMed Central Commentary Open Access Dual role of TRBP in HIV replication and RNA interference viral diversion of a cellular pathway or evasion from antiviral immunity Anne Gatignol Sébastien Lainé and Guerline Clerzius Address Virus-Cell Interactions Laboratory Lady Davis Institute for Medical Research and Department of Medicine and Microbiology Immunology McGill University Montréal Québec Canada Email Anne Gatignol - anne.gatignol@mcgill.ca Sébastien Lainé - sebastienlaine@hotmail.com Guerline Clerzius - gclerzius@yahoo.ca Corresponding author Published 27 October 2005 Received 28 September 2005 Accepted 27 October 2005 Retrovirology 2005 2 65 doi 10.1186 1742-4690-2-65 H This article is available from http www.retrovirology.com content 2 1 65 2005 Gatignol et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Increasing evidence indicates that RNA interference RNAi may be used to provide antiviral immunity in mammalian cells. Human micro mi RNAs can inhibit the replication of a primate virus whereas a virally-encoded miRNA from HIV inhibits its own replication. Indirect proof comes from RNAi suppressors encoded by mammalian viruses. Influenza NSI and Vaccinia E3L proteins can inhibit RNAi in plants insects and worms. HIV-1 Tat protein and Adenovirus VA RNAs act as RNAi suppressors in mammalian cells. Surprisingly many RNAi suppressors are also inhibitors of the interferon IFN -induced protein kinase R PKR but the potential overlap between the RNAi and the IFN pathways remains to be determined. The link between RNAi as an immune response and the IFN pathway may be formed by a cellular protein TRBP which has a dual role in HIV replication and RNAi. TRBP has been isolated as an HIV-1 TAR RNA binding