tailieunhanh - Báo cáo y học: " A modeling and simulation study of siderophore mediated antagonism in dual-species biofilms"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A modeling and simulation study of siderophore mediated antagonism in dual-species biofilms. | Theoretical Biology and Medical Modelling BioMed Zentral Research Open Access A modeling and simulation study of siderophore mediated antagonism in dual-species biofilms Hermann J Eberl 1 and Shannon Collinson2 Address department of Mathematics and Statistics University of Guelph Guelph On Canada N1G 2W1 and department of Mathematics and Statistics York University Toronto On Canada M3J 1P3 E-mail Hermann J Eberl - heberl@ Shannon Collinson - mscolli@ Corresponding author Published 22 December 2009 Received 14 October 2009 Theoretical Biology and Medical Modelling 2009 6 30 doi 1742-4682-6-30 Accepted 22 December 2009 This article is available from http content 6 1 30 2009 Eberl and Collinson licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Several bacterial species possess chelation mechanisms that allow them to scavenge iron from the environment under conditions of limitation. To this end they produce siderophores that bind the iron and make it available to the cells later on while rendering it unavailable to other organisms. The phenomenon of siderophore mediated antagonism has been studied to some extent for suspended populations where it was found that the chelation ability provides a growth advantage over species that do not have this possibility. However most bacteria live in biofilm communities. In particular Pseudomonas fluorescens and Pseudomonas putida the species that have been used in most experimental studies of the phenomenon are known to be prolific biofilm formers but only very few experimental studies of iron chelation have been published to date for the biofilm setting. We address this question in the present study. Methods Based on a .