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Báo cáo khoa học: "A Toxicity of polymyxins: a systematic review of the evidence from old and recent studies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. | Available online http ccforum.eom content 10 1 R27 Research Toxicity of polymyxins a systematic review of the evidence from old and recent studies Matthew E Falagas1 2 3 and Sofia K Kasiakou1 1Alfa Institute of Biomedical Sciences AIBS Athens Greece 2Department of Medicine Henry Dunant Hospital Athens Greece 3Department of Medicine Tufts University School of Medicine Boston Massachusetts USA Corresponding author Matthew E Falagas matthew.falagas@tufts.edu Received 7 Oct 2005 Revisions requested 3 Jan 2006 Revisions received 13 Jan 2006 Accepted 18 Jan 2006 Published 13 Feb 2006 Critical Care 2006 10 R27 doi 10.1186 cc3995 This article is online at http ccforum.com content 10 1 R27 2006 Falagas and Kasiakou licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background The increasing problem of multidrug-resistant Gram-negative bacteria causing severe infections and the shortage of new antibiotics to combat them has led to the reevaluation of polymyxins. These antibiotics were discovered from different species of Bacillus polymyxa in 1947 only two of them polymyxin B and E colistin have been used in clinical practice. Their effectiveness in the treatment of infections due to susceptible Gram-negative bacteria including Pseudomonas aeruginosa and Acinetobacter baumannii has not been generally questioned. However their use was abandoned except in patients with cystic fibrosis because of concerns related to toxicity. Methods We reviewed old and recent evidence regarding polymyxin-induced toxicity by searching Pubmed from 1950 until May 2005 . Results It was reported in the old literature that the use of polymyxins was associated with considerable toxicity mainly nephrotoxicity and neurotoxicity including .