tailieunhanh - Báo cáo khoa học: " Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity. | Yeo et al. Radiation Oncology 2010 5 56 http content 5 1 56 RADIATION ONCOLOGY RESEARCH Open Access Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer local control and toxicity Seung-Gu Yeo 1 2 Juree Kim2 6 Geum-Hee Kwak3 Ji-Young Kim4 Kyeongmee Park5 Eun Seok Kim1 and Sehwan Han3 Abstract Background To investigate the efficacy and safety of accelerated partial breast irradiation APBI via high-dose-rate HDR multicatheter interstitial brachytherapy for early-stage breast cancer. Methods Between 2002 and 2006 48 prospectively selected patients with early-stage breast cancer received APBI using multicatheter brachytherapy following breast-conserving surgery. Their median age was 52 years range 36-78 . A median of 34 Gy range 30-34 in 10 fractions given twice daily within 5 days was delivered to the tumor bed plus a 12 cm margin. Most 92 patients received adjuvant systemic treatments. The median follow-up was 53 months range 36-95 . Actuarial local control rate was estimated from surgery using Kaplan-Meier method. Results Local recurrence occurred in two patients. Both were true recurrence marginal miss and developed in patients with close cm surgical margin after 33 and 40 months. The 5-year actuarial local recurrence rate was . No regional or distant relapse and death has occurred to date. Late Grade 1 or 2 late skin and subcutaneous toxicity was seen in 11 and 26 patients respectively. The volumes receiving 100 and 150 of the prescribed dose were significantly higher in the patients with late subcutaneous toxicity p and respectively . Cosmesis was excellent to good in . Conclusions APBI using HDR multicatheter brachytherapy yielded local control toxicity and cosmesis comparable to those of conventional whole breast irradiation for select early-stage breast cancer. Patients with close resection margins may be ineligible for APBI. Background Over the last