tailieunhanh - Báo cáo khoa học: "Lack of Cetuximab induced skin toxicity in a previously irradiated field: case report and review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of Cetuximab induced skin toxicity in a previously irradiated field: case report and review of the literature. | Kanakamedala et al. Radiation Oncology 2010 5 38 http content 5 1 38 RADIATION ONCOLOGY CASE REPORT Open Access Lacklof Cetuximab induced skin toxicity in a previously irradiated field case report and review of the literature Madhava R Kanakamedala Satyaseelan Packianathan and Srinivasan Vijayakumar Abstract Introduction Mutation amplification or dysregulation of the EGFR family leads to uncontrolled division and predisposes to cancer. Inhibiting the EGFR represents a form of targeted cancer therapy. Case report We report the case of 79 year old gentlemen with a history of skin cancer involving the left ear who had radiation and surgical excision. He had presented with recurrent lymph node in the left upper neck. We treated him with radiation therapy concurrently with Cetuximab. He developed a skin rash over the face and neck area two weeks after starting Cetuximab which however spared the previously irradiated area. Conclusion The etiology underlying the sparing of the previously irradiated skin maybe due to either decrease in the population of EGFR expressing cells or decrease in the EGFR expression. We raised the question that Is it justifiable to use EGFR inhibitors for patients having recurrence in the previously irradiated field We may need further research to answer this question which may guide the physicians in choosing appropriate drug in this scenario. Introduction The ErbB or epidermal growth factor family is a family of four structurally related EGFR ErbB1 HER1 ErbB2 neu HER2 ErbB3 HER3 and ErbB4 HER4. ErbB receptors are comprised of an extracellular region or ectodomain a single transmembrane spanning region and a cytoplasmic tyrosine kinase domain 1 . Epidermal growth factor receptors EGFR upon activation by their respective ligands undergo a transformation from the inactive monomeric form into an active homo or hetero-dimer. This process stimulates its intrinsic intracellular proteintyrosine kinase activity 2 . Mutation .