tailieunhanh - Báo cáo khoa học: "Is standard breast-conserving therapy (BCT) in elderly breast cancer patients justified? A prospective measurement of acute toxicity according CTC-classification"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Is standard breast-conserving therapy (BCT) in elderly breast cancer patients justified? A prospective measurement of acute toxicity according CTC-classification. | Galalae et al. Radiation Oncology 2010 5 103 http content 5 1 103 RADIATION ONCOLOGY RESEARCH Open Access Is standard breast-conserving therapy BCT in elderly breast cancer patients justified A prospective measurement of acute toxicity according CTC-classification Razvan M Galalae1 2 Jurgen Schultze3 Kirsten Eilf3 Bernhard Kimmig2 3 Abstract Background Breast conserving therapy BCT is an accepted treatment for early-stage breast cancer. This study aimed to measure prospectively acute radiation-related toxicity and to create a comprehensive data base for longterm temporal analyses of 3D conformal adjuvant radiotherapy. The specific aspect of age has been neglected by traditional research. Therefore the impact of age on acute BCT toxicity should be also specifically adressed. Methods Toxicity was measured in 109 patients at initiation t1 during radiotherapy t2-t7 and 6 weeks after treatment completion t8 using a new topographic module. Organ systems were recorded in 15 scales and scored according to symptom intensity grade 0-5 based on CTC Common Toxicity Criteria -classification. Radiotherapy was virtually CT-based planned and applied with 6-MeV-photons. Mean total dose was Gy. Patients were stratified by age in 3 Groups 50 50-60 and 60 years. Results Registered toxicity was generally low. Mean overall-grade climbed from t1-t7 and dropped to t8 . Univariate analyses revealed slightly higher toxicity in older 60 years versus young patients 50 years in 2 scales only breast-symmetry p and arm function p . However in the scale appetite toxicity was higher in younger 50 years versus older 60 years patients p . Toxicity differences in all other scales were not significant. Between older 60 years and midaged patients 50-60 years no significant differences in toxicity were found. This was also true for the comparison between young 50 years versus midaged patient groups 50-60 years . Conclusion The treatment concept of

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