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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during. | Respiratory Research BioMed Central Research Open Access The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia R Jounblat2 H Clark2 P Eggleton3 S Hawgood4 PW Andrew1 and A Kadioglu 1 Address Department of Infection Immunity and Inflammation University of Leicester Leicester LE1 9HN UK 2MRC Immunochemistry Unit University of Oxford South Parks Road Oxford OX1 3QU UK institute of Biomedical and Clinical Sciences Peninsula Medical School Exeter EX1 2LU UK and 4Cardiovascular Research Institute and Department of Paediatrics University of California San Francisco San Francisco California USA Email R Jounblat - rania.jumblat@lau.edu.lb H Clark - howard.clark@bioch.ox.ac.uk P Eggleton - paul.eggleton@pms.ac.uk S Hawgood - hawgood@itsa.ucsf.edu PW Andrew - pwa@le.ac.uk A Kadioglu - ak13@le.ac.uk Corresponding author Published 28 October 2005 Received II July 2005 Respiratory Research 2005 6 126 doi 10.1186 1465-9921-6-126 Accepted 28 October 2005 This article is available from http respiratory-research.com content 6 1 126 2005 Jounblat et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have shown previously that surfactant protein D SP-D binds and agglutinates Streptococcus pneumoniae in vitro. In this study the role of SP-D in innate immunity against S. pneumoniae was investigated in vivo by comparing the outcome of intranasal infection in surfactant protein D deficient SP-D- - to wildtype mice SP-D . Deficiency of SP-D was associated with enhanced colonisation and infection of the upper and lower respiratory tract and earlier onset and longer persistence of bacteraemia. Recruitment of neutrophils to inflammatory sites in the lung was .