tailieunhanh - Báo cáo y học: "The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors. | Kokebie et al. Arthritis Research Therapy 2011 13 R50 http content 13 2 R50 RESEARCH ARTICLE Open Access The role of synovial fluid markers of catabolism and anabolism in osteoarthritis rheumatoid arthritis and asymptomatic organ donors 12 3 3 4 13 Rediet Kokebie Rohit Aggarwal Sukhwinderjit Lidder Arnavaz A Hakimiyan David C Rueger Joel A Block 1 and Susan Chubinskaya1 3 5 Abstract Introduction The purpose of this study was to correlate the level of anabolic and catabolic biomarkers in synovial fluid SF from patients with rheumatoid arthritis RA patients with osteoarthritis OA and asymptomatic organ donors. Methods SF was collected from the knees of 45 OA 22 RA patients and 20 asymptomatic organ donors. Eight biomarkers were selected and analyzed by using an enzyme-linked immunosorbent assay interleukin IL -1 IL-6 IL-8 and IL-11 leukemia-inhibitory factor LIF cartilage oligomeric protein COMP osteocalcin and osteogenic protein 1 OP-1 . Data are expressed as medians interquartile ranges . The effects of sex and disease activity were assessed on the basis of the Western Ontario and McMaster Universities index score for patients with OA and on the basis of white blood cell count erythrocyte sedimentation rate and C-reactive protein level for patients with RA. Results The mean ages SD of the patients were as follows 53 9 years for patients with OA 54 11 years for patients with RA and 52 7 years for asymptomatic organ donors. No effect of participants sex was identified. In the SF of patients with RA four of five cytokines were higher than those in the SF of patients with OA and those of asymptomatic organ donors. The most significant differences were found for IL-6 and IL-8 where IL-6 concentration in SF of patients with RA was almost threefold higher than that in patients with OA and fourfold higher than that in asymptomatic donor controls pg ml 1 vs. pg ml vs. pg ml P and P respectively . IL-8 .