tailieunhanh - Báo cáo y học: "Chlamydia trachomatis Infection of Human Trophoblast Alters Estrogen and Progesterone Biosynthesis: an insight into role of infection in pregnancy sequelae."

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Chlamydia trachomatis Infection of Human Trophoblast Alters Estrogen and Progesterone Biosynthesis: an insight into role of infection in pregnancy sequelae | Int. J. Med. Sci. 2007 4 223 International Journal of Medical Sciences ISSN 1449-1907 2007 4 4 223-231 Ivyspring International Publisher. All rights reserved Research Paper Chlamydia trachomatis Infection of Human Trophoblast Alters Estrogen and Progesterone Biosynthesis an insight into role of infection in pregnancy sequelae Anthony A. Azenabor Patrick Kennedy and Salvatore Balistreri Department of Health Sciences University of Wisconsin Milwaukee WI 53211 USA Correspondence to Dr. Anthony A. Azenabor Enderis Hall Room 469 University of Wisconsin 2400 E. Hartford Avenue Milwaukee WI 53211 USA. Phone 414 229-5637 Fax 414 229-2619 Email aazenabo@ Received Accepted Published The trophoblast cells are in direct contactwith endometrial tissues throughout gestation playing important early roles in implantation and placentation. The physiologic significance and the operating mechanisms involved in probable altered trophoblast functions folloWing Chlamydia trachomatis infection were investigated to determine if C. trachomatis initiates productive infection in trophoblast effects of such event on the biosynthesis of cholesterol and its derivatives estrogen and progesterone and the regulator of the biosynthesis of these hormones human chorionic gonadotropin. Chlamydia trachomatis exhibited productive infection in trophoblast typified by inclusion formation observed when chlamydia elementary bodies were harvested from trophoblast and titrated onto HEp-2 cells. Assessment of the status of C. trachomatis in trophoblast showed a relative increase in protein of HSP-60 compared with MOMP features suggestive of chlamydial chronicity. There was a decrease m cellular cholesterol of chlamydia infected trophoblast and a down regulation of HMG-CoA reductase. The levels of estrogen and progesterone were decreased while the expression of aromatase and adrenodoxin reductase was up regulated. Also there was a decrease in human .

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