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Báo cáo y học: " Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients"

Tham khảo luận văn - đề án 'báo cáo y học: " smoking status and tumor necrosis factor-alpha mediated systemic inflammation in copd patients"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Tanni et al. Journal of Inflammation 2010 7 29 http www.journal-inflammation.eom content 7 1 29 JOURNAL OF INFLAMMATION RESEARCH Open Access Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients Suzana ETanni 21 Nilva RG Pelegrino21 Aparecida YO AngelelP2 Camila Correa22 and Irma Godoy21 Abstract Background Smoking cause airway and systemic inflammation and COPD patients present low grade inflammation in peripheral blood. However data on the influence of smoking itself on systemic inflammation in COPD patients are scarce. This study investigated the association between inflammation smoking status and disease. Methods A cross-sectional analysis comparing 53 COPD ex-smokers 24 COPD current smokers 24 current smoker controls and 34 never-smoker controls was performed. Assessments included medical history body composition spirometry and plasma concentration of tumor necrosis factor-alpha TNF-a interleukins IL -6 IL-8 and C-reactive protein CRP . Results Our exploratory analysis showed that serum TNF-a was higher in COPD current smokers 4.8 4.2-5.8 pg mL and in current smoker controls 4.8 4.2-6.1 pg mL when compared to COPD ex-smokers 4.3 3.9-4.9 pg mL p 0.02 and to never-smoker controls 3.7 3.4-4.0 pg mL p 0.001 . Multiple regression results with and without adjustment for covariates were consistent with the hypothesis that TNF-a levels were associated with smoking status in both models p 0.001 and p 0.001 . IL-6 and CRP were significantly higher in COPD patients when compared to smoker and never-smoker controls and the multiple regression analysis confirmed the association of these mediators with disease but not with smoking status p 0.001 and p 0.001 . IL-8 had only a borderline association with disease in both models p 0.069 and p 0.053 . No influence of disease severity inhaled corticosteroid fat-free mass FFM depletion and long term oxygen therapy LTOT use on systemic inflammation was found. Conclusion Smoking may influence