tailieunhanh - Báo cáo y học: "Smoking–gender interaction and risk for rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Smoking–gender interaction and risk for rheumatoid arthritis. | Arthritis Research Therapy Vol 5 No 3 Krishnan et al. Research article Open Access Smoking-gender interaction and risk for rheumatoid arthritis Eswar Krishnan1 Tuulikki Sokka2 3 Pekka Hannonen2 1 Department of Medicine Stanford University Palo Alto California USA 2Jyvaskyla Central Hospital Jyvaskyla Finland 3Vanderbilt University Nashville Tennessee USA Corresponding author Eswar Krishnan e-mail eswar_krishnan@ Received 27 Nov 2002 Revisions requested 10 Jan 2003 Revisions received 20 Jan 2003 Accepted 21 Feb 2003 Published 24 Mar 2003 Arthritis Res Ther 2003 5 R158-R162 DOI ar750 2003 Krishnan et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The present case-control study was conducted to investigate the relationship between smoking and rheumatoid arthritis and to investigate formally the interaction between sex smoking and risk for developing rheumatoid arthritis. The study was performed in the Central District of Finland. Cases were patients with rheumatoid arthritis and the control group was a random sample of the general population. Logistic regression models were used to evaluate the effect of smoking on risk for rheumatoid arthritis after adjusting for the effects of age education body mass index and indices of general health and pain. Overall 1095 patients with rheumatoid arthritis and 1530 control individuals were included. Patients were older less well educated more disabled and had poorer levels of general Keywords etiology interaction risk rheumatoid arthritis sex smoking health as compared with control individuals all P . Preliminary analyses revealed the presence of substantial statistical interaction between smoking and sex P . In separate multivariable analyses past history of smoking

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