tailieunhanh - Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. | Available online http content 10 3 R52 Research article Genetic polymorphisms in PTPN22 PADI-4 and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies evidence of gene-environment interactions with heavy cigarette smoking Karen H Costenbader1 Shun-Chiao Chang2 3 Immaculata De Vivo2 3 Robert Plenge1 and Elizabeth W Karlson1 Open Access Division of Rheumatology Immunology and Allergy Department of Medicine Brigham and Women s Hospital Harvard Medical School Boston Massachusetts 02115 USA 2Channing Laboratory Department of Medicine Brigham and Women s Hospital Harvard Medical School 75 Francis Street Boston Massachusetts 02115 USA department of Epidemiology Harvard School of Public Health 677 Huntington Avenue Boston Massachusetts 02115 USA Corresponding author Karen H Costenbader kcostenbader@ Received 17 Sep 2007 Revisions requested 14 Nov 2007 Revisions received 27 Mar 2008 Accepted 7 May 2008 Published 7 May 2008 Arthritis Research Therapy 2008 10 R52 doi ar2421 This article is online at http content 10 3 R52 2008 Costenbader et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction PTPN22 PADI-4 and CTLA-4 have been associated with risk for rheumatoid arthritis RA . We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts adjusting for confounding factors and testing for interactions with smoking. Methods We studied RA risk associated with PTPN22 rs2476601 PADI-4 rs2240340 and CTLA-4 rs3087243 in the Nurses Health Study NHS and NHSII. Participantsjn NHS were aged 30 to 55 years at entry in 1976 those in NHSII were aged 25 to 42 years .

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