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Báo cáo y học: " Neutrophil cannibalism – a back up when the macrophage clearance system is insufficient"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Neutrophil cannibalism – a back up when the macrophage clearance system is insufficient. | Respiratory Research BioMed Central Research Neutrophil cannibalism - a back up when the macrophage clearance system is insufficient Kristina Rydell-Tormanen Lena Uller and Jonas S Erjefalt Open Access Address Div. Vascular and Airway Research Dept. Experimental Medical Science Lund University Lund Sweden Email Kristina Rydell-Tormanen - Kristina.Rydell-Tormanen@med.lu.se Lena Uller - Lena.Uller@med.lu.se Jonas S Erjefalt - Jonas.Erjefalt@med.lu.se Corresponding author Published 14 December 2006 Received 27 April 2006 Accepted 14 December 2006 Respiratory Research 2006 7 143 doi 10.1186 1465-9921-7-143 This article is available from http respiratory-research.cOm content 7 1 143 2006 Rydell-Tormanen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background During a lipopolysaccharide-induced lung inflammation a massive accumulation of neutrophils occurs which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However in cases of extensive apoptosis the normal clearance system may fail resulting in extensive neutrophil secondary necrosis. The aim of this study was to explore the hypothesis that neutrophils in areas of the lung with extensive cellular infiltration contribute to clearance by phagocytosing apoptotic cells and or cell debris derived from secondary necrosis. Methods Intranasal lipopolysaccharide administration was used to induce lung inflammation in mice. The animals were sacrificed at seven time points following administration bronchoalveolar lavage was performed and tissue samples obtained. Electron microscopy and histochemistry was used to assess neutrophil phagocytosis. Results .