tailieunhanh - Báo cáo y học: "Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis. | Available online http content 7 2 R250 Research article Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis Franco Capsoni1 Piercarlo Sarzi-Puttini2 Fabiola Atzeni2 Francesca Minonzio1 Paola Bonara1 Andrea Doria3 and Mario Carrabba2 Department of Internal Medicine Ospedale Maggiore Policlinico IRCCS University of Milan Milan Italy 2Rheumatology Unit Ospedale L Sacco University of Milan Milan Italy 3Division of Rheumatology University of Padua Italy Corresponding author Franco Capsoni Received 3 Sep 2004 Revisions requested 14 Oct 2004 Revisions received 25 Oct 2004 Accepted 15 Nov 2004 Published 10 Jan 2005 Arthritis Res Ther 2005 7 R250-R255 DOI ar1477 2005 Capsoni et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Neutrophils are known to be targets for the biological activity of tumour necrosis factor TNF -a in the pathogenensis of rheumatoid arthritis RA . Therefore these cells may be among the targets of anti-TNF-a therapy. In this study we evaluated the effect of therapy with adalimumab a fully human anti-TNF-a mAb dosage 40 mg subcutaneously every other week on certain phenotypic and functional aspects of neutrophils obtained from 10 selected patients with RA and 20 healthy control individuals. Peripheral blood neutrophils were obtained at baseline and during anti-TNF-a therapy 2 6 and 12 weeks after the first administration of adalimumab . All patients had been receiving a stable regimen of hydroxychloroquine methotrexate and prednisone for at least 3 months before and during the study. Baseline neutrophil chemotaxis was significantly decreased in RA patients when compared with control individuals P . Two weeks