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Báo cáo y học: " Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study | Respiratory Research BioMed Central Research Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis a case-control study Andrew J Ghio 1 Jacqueline G Stonehuerner1 Judy H Richards1 Kay M Crissman1 Victor L Roggli2 Claude A Piantadosi3 and Martha Sue Carraway1 Address National Health and Environmental Effects Research Laboratory Environmental Protection Agency Research Triangle Park NC 27711 USA departments of Pathology and Medicine Duke University Medical Center Durham NC 27710 USA and department of Medicine Duke University Medical Center Durham NC 27710 USA Email Andrew J Ghio - ghio.andy@epa.gov Jacqueline G Stonehuerner - stonehuerner.jackie@epa.gov Judy H Richards - richards.judy@epa.gov Kay M Crissman - crissman.kay@epa.gov Victor L Roggli - roggl002@mc.duke.edu Claude A Piantadosi - piant001@mc.duke.edu Martha Sue Carraway - carra001@mc.duke.edu Corresponding author Open Access Published 23 January 2008 Received 4 September 2007 Respiratory Research 2008 9 10 doi 10.1186 1465-9921-9-10 Accepted 23 January 2008 This article is available from http respiratory-research.cOm content 9 1 10 2008 Ghio et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles such as silica and certain infections can cause secondary pulmonary alveolar proteinosis PAP we tested the hypothesis that idiopathic PAP is associated with an altered iron homeostasis in the human lung. Methods Healthy volunteers n 20 and patients with idiopathic PAP n 20 .