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Báo cáo y học: " Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells. | BioMed Central Respiratory Research Research Inhibition of SOC Ca2 NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells Cong Wang11 2 3 Ji-Feng Lit1 2 3 Lan Zhao14 Jie Liu2 3 Jun Wan1 2 3 Yue Xiu Wang1 2 3 Jun Wang 1 2 3 and Chen Wang 1 3 Address 1Beijing Institute of Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing PR China 2Department of Physiology Capital Medical University Beijing PR China 3Department of Respiratory Disease Capital Medical University Beijing PR China and 4Experimental Medicine and Toxicology Imperial College London Hammersmith Hospital UK Email Cong Wang - congcongwan@gmail.com Ji-Feng Li - kathleenljf@yahoo.com.cn Lan Zhao - l.zhao@imperial.ac.uk Jie Liu - flowers817105@gmail.com Jun Wan - Blueswan1975@yahoo.com.cn Yue Xiu Wang - yuexiuw111@sina.com Jun Wang -wangjunbw@gmail.com Chen Wang -cyh-birm@263.net Corresponding authors tEqual contributors Open Access Published II December 2009 Received 28 April 2009 Respiratory Research 2009 10 123 doi 10.1186 1465-9921-10-123 Accepted 1 1 December 2009 This article is available from http respiratory-research.cOm content 10 1 123 2009 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Sildenafil a potent phosphodiesterase type 5 PDE5 inhibitor has been proposed as a treatment for pulmonary arterial hypertension PAH . The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells PASMC is unclear. Nuclear translocation of nuclear factor of activated T-cells NFAT is thought to be involved in PASMC proliferation and PAH. Increase in cytosolic free Ca2 Ca2 i is a prerequisite for NFAT nuclear translocation. Elevated Ca2 i