tailieunhanh - Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases. | Pamuk and Tsokos Arthritis Research Therapy 2010 12 222 http content 12 6 222 REVIEW Spleen tyrosine kinase inhibition in the treatment of autoimmune allergic and autoinflammatory diseases Omer N Pamuk -2 and George C Tsokos 1 Abstract Spleen tyrosine kinase Syk is involved in the development of the adaptive immune system and has been recognized as being important in the function of additional cell types including platelets phagocytes fibroblasts and osteoclasts- and in the generation of the inflammasome. Preclinical studies presented compelling evidence that Syk inhibition may have therapeutic value in the treatment of rheumatoid arthritis and other forms of arthritis systemic lupus erythematosus autoimmune cytopenias and allergic and autoinflammatory diseases. In addition Syk inhibition may have a place in limiting tissue injury associated with organ transplant and revascularization procedures. Clinical trials have documented exciting success in the treatment of patients with rheumatoid arthritis autoimmune cytopenias and allergic rhinitis. While the extent and severity of side effects appear to be limited so far larger studies will unravel the risk involved with the clinical benefit. 1. Introduction Spleen tyrosine kinase Syk is a cytoplasmic tyrosine kinase of 72 kDa and a member of the ZAP70 Z-chain-associated protein kinase of 70 kDa Syk family of the non-receptor-type protein tyrosine kinases PTKs 1 2 and contains two SRC homology 2 SH2 domains and a kinase domain 3 . Syk is expressed in most hematopoietic cells including B cells immature T cells mast cells neutrophils macrophages and platelets 1 3 4 and is important in signal transduction in these cells 2 5 . Correspondence gtsokos@ Division of Rheumatology Beth Israel Deaconess Medical Center Harvard Medical School 330 Brookline Avenue CLS-928 Boston MA 021 5 USA Full list of author information is available at the end of the article 2 BioMed Central 2010 BioMed .