tailieunhanh - Báo cáo y học: "Regular mosaic pattern development: A study of the interplay between lateral inhibition, apoptosis and differential adhesion"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Regular mosaic pattern development: A study of the interplay between lateral inhibition, apoptosis and differential adhesion | Theoretical Biology and Medical Modelling BioMed Central Research Regular mosaic pattern development A study of the interplay between lateral inhibition apoptosis and differential adhesion Gregory J Podgorski1 Mayank Bansal2 and Nicholas S Flann 2 Open Access Address Biology Department and Center for Integrated Biosystems Utah State University Logan UT USA and 2Computer Science Department Utah State University Logan UT USA Email Gregory J Podgorski - podgorski@ Mayank Bansal - Nicholas S Flann - Corresponding author Published 31 October 2007 Received 24 May 2007 Theoretical Biology and Medical Modelling 2007 4 43 doi 1742-4682-4-43 Accepted 3 1 October 2007 This article is available from http content 4 1 43 2007 Podgorski et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background A significant body of literature is devoted to modeling developmental mechanisms that create patterns within groups of initially equivalent embryonic cells. Although it is clear that these mechanisms do not function in isolation the timing of and interactions between these mechanisms during embryogenesis is not well known. In this work a computational approach was taken to understand how lateral inhibition differential adhesion and programmed cell death can interact to create a mosaic pattern of biologically realistic primary and secondary cells such as that formed by sensory primary and supporting secondary cells of the developing chick inner ear epithelium. Results Four different models that interlaced cellular patterning mechanisms in a variety of ways were examined and .