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báo cáo khoa học: "DNA aneuploidy as a topographic malignant transformation pattern in a pleomorphic adenoma of long-term evolution: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: DNA aneuploidy as a topographic malignant transformation pattern in a pleomorphic adenoma of long-term evolution: a case report | Gallego et al. Journal of Medical Case Reports 2011 5 541 http www.jmedicalcasereports.eom content 5 1 541 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access DNA aneuploidy as a topographic malignant transformation pattern in a pleomorphic adenoma of long-term evolution a case report I rsremrt llddr i1 2 I I lie II moi ŨI túc ỈÁ ei v.ieel IO p troTi.e4 Poloc .lool Tomm .leo I itllll6 Loreiid Gdllego Luis Junquerd Josuc nenidiido Manuel F Fresno And Sdlds diiu lummdsu Cutilli Abstract Introduction We present d cdse of long-term evolution of d submdndibuldr pleomorphic ddenomd. There is little informdtion dbout topographic mdliyndnt transformation pdtterns of pleomorphic ddenomds. Case presentation We extensively dndlyze d yidnt submdndibuldr mixed tumor of 25-yedr evolution in d 57-yedr-old Cducdsidn womdn. Deoxyribonucleic dcid ploidy wds evdludted in different superficidl dnd deep dreds using flow cytometry dndlysis dnd correldted with pdthologicdl dnd immunohistochemicdl chdrdcteristics. Superficidl dreds exhibited d typicdl histologicdl pleomorphic ddenomd pdttern dnd were deoxyribonucleic dcid diploid. Deep sdmples showed deoxyribonucleic dcid dneuploidy dtypicdl histologicdl benign fedtures dnd expression of mdrkers involved dt dn edrly-stdge of mdligndnt trdnsformdtion such ds tumor protein 53 dnd dntigen Ki67. Conclusion These findings revedled thdt deep tumor compdrtments mdy be involved in the initidl stdges of mdligndnt trdnsformdtion. Deoxyribonucleic dcid ploidy dndlysis mdy provide dn ddditiondl didgnosis tool dnd indicdte uncertdin dreds thdt require cdreful study to dvoid didgnostic errors. Ldrger studies dre needed to confirm our results dnd to evdludte the usefulness of the technique. Introduction Pleomorphic adenomas PAs are the most common benign tumors arising in salivary glands and their malignant transformation to carcinoma ex pleomorphic adenomas CXPAs accounts for between 4.5 and 15 of all cancers of these glands 1 . The diagnosis of .