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Báo cáo y học: "Role of resistin as a marker of inflammation in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of resistin as a marker of inflammation in systemic lupus erythematosus. | Available online http arthritis-research.eom content 10 1 R15 Research article Role of resistin as a marker of inflammation in systemic lupus erythematosus Katarina Almehed Helena Forsblad d Elia Maria Bokarewa and Hans Carlsten Open Access Department of Rheumatology and Inflammation Research Sahlgrenska Academy at Goteborg University Guldhedsgatan 10 S-413 46 Goteborg Sweden Corresponding author Katarina Almehed katarina.almehed@vgregion.se Received 26 Sep 2007 Revisions requested 22 Nov 2007 Revisions received 23 Dec 2007 Accepted 30 Jan 2008 Published 30 Jan 2008 Arthritis Research Therapy 2008 10 R15 doi 10.1186 ar2366 This article is online at http arthritis-research.com content 10 1 R15 2008 Almehed et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Resistin is a cystein-rich secretory adipokine. It is proposed to have proinflammatory properties in humans. The aim of this study was to determine associations between serum levels of resistin and markers of inflammation and bone mineral density BMD in female patients with systemic lupus erythematosus SLE . Methods One hundred sixty-three female patients with SLE 20 to 82 years old were examined in a cross-sectional study. Venous blood samples were analyzed for resistin erythrocyte sedimentation rate ESR C-reactive protein creatinine fasting lipids complements tumor necrosis factor-alpha interleukin IL -1p IL-6 sIL-6R soluble IL-6 receptor ICTP C-terminal telopeptide of type I collagen and PINP N-terminal propeptide of type I procollagen . Simple and multiple regression analyses as well as logistic regression analyses were performed. Resistin in serum was compared with 42 healthy female controls with respect to age. Results Serum resistin levels