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Báo cáo khoa học: "Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma. | Shueng et al. Radiation Oncology 2011 6 95 http www.ro-journal.eom content 6 1 95 RADIATION ONCOLOGY RESEARCH Open Access Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma 14 1 12 3 3 2 Pei-Wei Shueng 1 Bing-Jie Shen Le-Jung Wu Li-Jen Liao Chi-Huang Hsiao Yu-Chin Lin Po-Wen Cheng Wu-Chia Lo2 Yee-Min Jen4 and Chen-Hsi Hsieh1 5 Abstract Background To evaluate the experience of induction chemotherapy followed by concurrent chemoradiationwith helical tomotherapy HT for nasopharyngeal carcinoma NPC . Methods Between August 2006 and December 2009 28 patients with pathological proven nonmetastatic NPC were enrolled. All patients were staged as IIB-IVB. Patients were first treated with 2 to 3 cycles of induction chemotherapy with EP-HDFL Epirubicin Cisplatin 5-FU and Leucovorin . After induction chemotherapy weekly based PFL was administered concurrent with HT. Radiation consisted of 70 Gy to the planning target volumes of the primary tumor plus any positive nodal disease using 2 Gy per fraction. Results After completion of induction chemotherapy the response rates for primary and nodal disease were 96.4 and 80.8 respectively. With a median follow-up after 33 months Range 13-53 months there have been 2 primary and 1 nodal relapse after completion of radiotherapy. The estimated 3-year progression-free rates for local regional locoregional and distant metastasis survival rate were 92.4 95.7 88.4 and 78.0 respectively. The estimated 3-year overall survival was 83.5 . Acute grade 3 4 toxicities for xerostomia and dermatitis were only 3.6 and 10.7 respectively. Conclusion HT for locoregionally advanced NPC is feasible and effective in regard to locoregional control with high compliance even after neoadjuvant chemotherapy. None of out-field or marginal failure noted in the current study confirms the potential benefits of treating NPC patients by image-guided radiation .