tailieunhanh - báo cáo khoa học: "Concurrent insulinoma and pancreatic adenocarcinoma: report of a rare case and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Concurrent insulinoma and pancreatic adenocarcinoma: report of a rare case and review of the literature | Athanasopoulos et al. World Journal of Surgical Oncology 2011 9 7 http content 9 1 7 7 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Concurrent insulinoma and pancreatic adenocarcinoma report of a rare case and review of the literature 1 1 1 23 Panagiotis G Athanasopoulos George Polymeneas Dionysios Dellaportas George Mastorakos Evi Kairi Dionysios Voros1 Abstract Pancreatic adenocarcinoma is the 5th leading cause of cancer-related death in Western countries and insulinomas are rare endocrine neoplasms of the pancreas. The concurrent appearance of pancreatic adenocarcinoma and insulinoma is very rare and to the best of our knowledge has never been reported again. Herein we present such an occurrence in a 74-year-old man. Resection of a mass in the uncinate process of the pancreas revealed pancreatic adenocarcinoma with severe desmoplastic reaction. Two years later due to symptomatology persistence the patient was re-examined and a new 2cm mass in the uncinate process was found leading to surgery which demonstrated a 2cm endocrine islet-cell tumor. Establishing a diagnosis in patients with insulinoma is difficult and the imaging studies still have low sensitivity and specificity except for intra-operative ultrasonography which is the most accurate method detecting 90 of these lesions. Background Pancreatic endocrine neoplasms are rare tumours with a reported incidence of four cases per million patients per year 1 . Of these tumours insulinomas are the most common and typically are sporadic and solitary masses affecting individuals 30-60 years old with equal distribution among genders 2 . On the other hand pancreatic adenocarcinoma is the 5th leading cause of cancer death in Western countries and the second cause of cancer death among gastrointestinal tumors 3 . An unusual occurrence of concomitant pancreatic adenocarcinoma and insulinoma in a 74-year-old man is presented herein. Case Presentation A 74-year-old man was admitted to our .

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