tailieunhanh - Báo cáo khoa học: "Intensity modulated radiotherapy with concurrent chemotherapy for larynx preservation of advanced resectable hypopharyngeal cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Intensity modulated radiotherapy with concurrent chemotherapy for larynx preservation of advanced resectable hypopharyngeal cancer. | Huang etal. Radiation Oncology 2010 5 37 http content 5 1 37 RADIATION ONCOLOGY RESEARCH Open Access Intensity modulated radiotherapy with concurrent chemotherapy for larynx preservation of advanced resectable hypopharyngeal cancer Wen-Yen Huang 1 Yee-Min Jen 1 Chang-Ming Chen1 Yu-Fu Su1 Chun-Shu Lin1 Yaoh-Shiang Lin2 Ying-Nan Chang2 Hsing-Lung Chao1 Kuen-Tze Lin1 and Li-Ping Chang1 Abstract Background To analyze the rate of larynx preservation in patients of locally advanced hypopharyngeal cancer treated with intensity modulated radiotherapy IMRT plus concurrent chemotherapy and compare the results with patients treated with primary surgery. Methods Between January 2003 and November 2007 14 patients were treated with primary surgery and 33 patients were treated with concurrent chemoradiotherapy CCRT using IMRT technique. Survival rate larynx preservation rate were calculated with the Kaplan-Meier method. Multivariate analysis was conducted for significant prognostic factors with Cox-regression method. Results The median follow-up was months for all patients and months for those alive. The 5-year overall survival rate was 33 and 44 for primary surgery and definitive CCRT respectively p . The 5-year functional larynx-preservation survival after IMRT was 40 . Acute toxicities were common but usually tolerable. The rates of treatment-related mucositis grade 2 and pharyngitis grade 3 were higher in the CCRT group. For multivariate analysis treatment response and cricoid cartilage invasion strongly correlated with survival. Conclusions IMRT plus concurrent chemotherapy may preserve the larynx without compromising survival. Further studies on new effective therapeutic agents are essential. Background Laryngopharyngectomy followed by radiotherapy RT chemoradiotherapy CRT has been one of treatment modalities for patients with hypopharyngeal cancer. However it leads to the loss of a functional larynx. Larynx preservation modality for .