tailieunhanh - Báo cáo khoa học: "Helical tomotherapy with concurrent capecitabine for the treatment of inoperable pancreatic cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Helical tomotherapy with concurrent capecitabine for the treatment of inoperable pancreatic cancer. | Ji et al. Radiation Oncology 2010 5 60 http content 5 1 60 RADIATION ONCOLOGY RESEARCH Open Access Helical tomotherapy with concurrent capecitabine for the treatment of inoperable pancreatic cancer Jeong-Seon Ji1 Chi-Wha Han 2 Jeong-Won Jang1 Bo-In Lee1 Byung-Wook Kim1 Hwang Choi1 Ji-Yoon Kim3 Young-Nam Kang4 Chul-Seung Kay5 and Ihl-Bohng Choi6 Abstract Background Helical tomotherapy an advanced intensity-modulated radiation therapy with integrated CT imaging permits highly conformal irradiation with sparing of normal tissue. Capecitabine a pro-drug of 5-FU that induces thymidine phosphorylase can achieve higher levels of intracellular 5-FU when administered concurrently with radiation. We evaluated the feasibility as well as the clinical outcome of concurrent administration of capecitabine with tomotherapy in patients with advanced pancreatic cancer. Methods Nineteen patients with advanced pancreatic cancer including primarily unresectable disease and recurrence after curative surgery were included in the study. Two planning target volumes PTV were entered PTV1 is gross tumor volume and PTV2 the volume of the draining lymph nodes. The total doses to target 1 and target 2 were 55 and 50 Gy respectively. Capecitabine at 1600 mg m2 day was administered on each day of irradiation. Results Twenty six measurable lesions were evaluated. Overall in-field response rate was partial responses were achieved in of the pancreatic masses of distant metastatic lesions and of regional lymph nodes. The median duration of follow-up after tomotherapy was months. None of the lesions showed in-field progression. Treatment was well tolerated with only minor toxicities such as grade 1 nausea one patient grade 1 hand-foot syndrome one patient and grade 1 2 fatigue three patients . Conclusions Helical tomotherapy with concurrent capecitabine is a feasible option without significant toxicities in patients with advanced pancreatic cancer. We .

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