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Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. | Available online http arthritis-research.eom content 4 4 241 Commentary The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases David A Horwitz J Dixon Gray and Song Guo Zheng The Division of Rheumatology and Immunology Department of Medicine Keck School of Medicine University of Southern California Los Angeles California USA Corresponding author David A Horwitz e-mail dhorwitz@hsc.usc.edu Received 5 December 2001 Revisions received 1 February 2002 Accepted 7 February 2002 Published 12 March 2002 Arthritis Res 2002 4 241-246 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive selfreactive T cells. Contact-dependent CD4 CD25 professional suppressor cells and other cytokineproducing CD4 and CD8 T-cell subsets mediate this protective function. Evidence will be reviewed that T cells primed with transforming growth factor TGF -p expand rapidly following restimulation. Certain CD4 T cells become contact-dependent suppressor cells and other CD4 and CD8 cells become cytokine-producing regulatory cells. This effect is dependent upon a sufficient amount of IL-2 in the microenvironment to overcome the suppressive effects of TGF-p. The adoptive transfer of these suppressor cells generated ex vivo can protect mice from developing chronic graft versus host disease with a lupus-like syndrome and alter the course of established disease. These data suggest that autologous T cells primed and expanded with TGF-p have the potential to be used as a therapy for patients with systemic lupus erythematosus and other chronic inflammatory diseases. This novel adoptive immunotherapy also has the potential to prevent the rejection of allogeneic transplants. Keywords autoimmunity IL-2 regulatory T cells systemic lupus erythematosus transforming growth factor-p Introduction It has become evident that .