tailieunhanh - Báo cáo y học: "Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. | Available online http content 11 1 R15 Research article Antirheumatic drug response signatures in human chondrocytes potential molecular targets to stimulate cartilage regeneration Kristin Andreas1 Thomas Haupl2 Carsten Lubke3 Jochen Ringe1 Lars Morawietz4 Anja Wachtel1 Michael Sittinger1 and Christian Kaps5 Tissue Engineering Laboratory and Berlin - Brandenburg Center for Regenerative Therapies Department of Rheumatology Charité -Universitatsmedizin Berlin Tucholskystrasse 2 10117 Berlin Germany 2Tissue Engineering Laboratory Department of Rheumatology Charité - Universitatsmedizin Berlin Tucholskystrasse 2 10117 Berlin Germany 3University of Applied Sciences Wildau Biosystems Technology Bahnhofstrasse 1 15745 Wildau Germany 4Institute of Pathology Charité - Universitatsmedizin Berlin Charitéplatz 1 10117 Berlin Germany 5TransTissueTechnologies GmbH Tucholskystrasse 2 10117 Berlin Germany Corresponding author Kristin Andreas Received 16 Sep 2008 Revisions requested 10 Oct 2008 Revisions received 8 Jan 2009 Accepted 3 Feb 2009 Published 3 Feb 2009 Arthritis Research Therapy 2009 11 R15 doi ar2605 This article is online at http content 11 1 R15 2009 Andreas et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Rheumatoid arthritis RA leads to progressive destruction of articular cartilage. This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and pharmacological target genes that are involved in cartilage dysfunction and regeneration. Methods An interactive in vitro cultivation system composed of human chondrocyte alginate cultures and conditioned

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