tailieunhanh - Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline. | Int. J. Med. Sci. 2004 1 2 76-91 76 International Journal of Medical Sciences ISSN 1449-1907 2004 1 2 76-91 2004 Ivyspring International Publisher. All rights reserved Review Analysis Received Accepted Published Gene Therapy The Potential Applicability of Gene Transfer Technology to the Human Germline Kevin R. Smith School of Contemporary Sciences University of Abertay Dundee DD1 1HG United Kingdom Abstract The theoretical possibility of applying gene transfer methodologies to the human germline is explored. Transgenic methods for genetically manipulating embryos may in principle be applied to humans. In particular microinjection of retroviral vector appears to hold the greatest promise with transgenic primates already obtained from this approach. Sperm-mediated gene transfer offers potentially the easiest route to the human germline however the requisite methodology is presently underdeveloped. Nuclear transfer cloning offers an alternative approach to germline genetic modification however there are major health concerns associated with current nuclear transfer methods. It is concluded that human germline gene therapy remains for all practical purposes a future possibility that must await significant and important advances in gene transfer technology. Key words gene targeting gene therapy genetic modification pronuclear microinjection sperm-mediated gene transfer Author biography Kevin Smith lectures in genetics and physiology in the School of Contemporary Sciences University of Abertay Dundee United Kingdom. His research interests include transgenesis gene therapy and bioethics. He is an experienced review article writer and has published several excellent reviews in the fields of transgenesis gene therapy and bioethics. Corresponding address K. R. Smith School of Contemporary Sciences University of Abertay Dundee Baxter Building Dundee DD1 1HG United Kingdom Phone 44 0 01382 308664 Email Int. J. Med.