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Báo cáo khoa học: "Renal cell cancer without a renal primary"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Renal cell cancer without a renal primary | Wayne et al. World Journal of Surgical Oncology 2010 8 18 http www.wjso.eom content 8 1 18 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Renal cell cancer without a renal primary M Wayne W Wang J Bratcher B Cumani F Kasmin A Cooperman Abstract Renal cell carcinoma has been increasing in incidence over the past two decades. Men are affected more than women and metastatic disease at presentation occurs in up to one third of patients. Metastasis can occur to virtually any organ and involvement of multiple organs is not uncommon. To date no reports have been found of metastatic disease without a renal primary. We present a case of renal cell cancer initially presenting as a subcutaneous mass with subsequent pancreatic and parotid gland metastases in absence of a primary renal source. Background In the United States renal cell carcinoma RCC has incidence in excess of 30 000 cases with 12 000 deaths every year from the disease 1 . It occurs predominantly in males in their sixth to eight decade of life and African Americans have a 10-20 higher incidence 2 . RCC is well known for its ability to metastasize to nearly every organ system of the body. Metastasis usually occurs several years after identification of the renal primary but up to 30 of patients have metastatic disease on initial presentation 3 . The most common targets for metastases are lung bone lymph nodes adrenal glands brain liver and contralateral kidney 4 . In contrast pancreatic and cutaneous involvement is exceedingly rare occurring approximately 0.25-3 and 3.3 of the time respectively 5 . Metastatic RCC is typically classified as either synchronous detected at the same time as primary tumors or metachronous detected after a time interval from primary tumor normally 6 months . In fact it is not uncommon for metastatic pancreatic lesions to develop several years after nephrectomy 6 . RCC with pancreatic involvement can be a diagnostic challenge in differentiating between primary pancreatic .