tailieunhanh - Báo cáo khoa học: "Leptomeningeal carcinomatosis from renal cell cancer: treatment attempt with radiation and sunitinib (case report)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Leptomeningeal carcinomatosis from renal cell cancer: treatment attempt with radiation and sunitinib (case report) | Dalhaug et al. World Journal of Surgical Oncology 2010 8 36 http content 8 1 36 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Leptomeningeal carcinomatosis from renal cell cancer treatment attempt with radiation and sunitinib case report Astrid Dalhaug 1 Ellinor Haukland1 and Carsten Nieder 1 2 Abstract A case of leptomeningeal carcinomatosis in a patient with known brain and lung metastases from renal cell cancer without previous systemic therapy is presented. Neoplastic meningitis NM developed 31 months after first diagnosis of simultaneous extra- and intracranial recurrence of kidney cancer and surgical resection of a cerebellar metastasis. In spite of local radiotherapy to the macroscopic NM lesions in the cervical and lumbar spine followed by initiation of sunitinib the patient succumbed to his disease 4 months after the diagnosis of NM. The untreated lung metastases progressed very slowly during almost 3 years of observation. This case illustrates important issues around both biological behaviour and treatment approaches in metastatic renal cell cancer. Background Brain metastases from renal cell carcinoma might develop many years after primary nephrectomy and continue to represent a formidable challenge 1 . With increasing numbers of local and systemic treatment options the issue of patient selection gains importance. While surgery and stereotactic radiosurgery SRS provide long-term local control of macroscopic disease development of new central nervous system lesions can often be observed. Some patients might even present with leptomeningeal carcinomatosis or so called neoplastic meningitis NM . Only few cases of NM from renal cell carcinoma treated with contemporary systemic approaches have been reported 2 3 . Therefore the present case illustrates important aspects around potential treatment options. Case presentation A 72-year-old male presented to his family doctor with a 3 week history of headache and dizziness. His medical .

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