tailieunhanh - báo cáo khoa học: "Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma | Journal of Experimental Clinical Cancer Research Ronkainen et al. Journal of Experimental Clinical Cancer Research 2011 30 84 http content 30 1 84 RESEARCH Open Access Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma l-ltinm Dnn 1 2inon1 I D ci Hir il ncl i2t c il mnil33 IZ-jf-ri c i mnah4 Titnri k Dtiitiix nncin5 c Qol nHor6 7 2ncl ndlllld nonkdinen Pdsi Hllvlkuskl Sdlld Kduppild KdUl S vuopdld limo K Pddvuilcll KdUl S Seldnder dnd Markku H Vddrdld1 3 Abstract Background Toll-llke receptor 9 TLR9 is d celluldr DNA-receptor whose dctívdtíon with cogndte ligdnds triggers dn Immune redctlon with incredsed production of lnfldmmdtory cytoklnes. The dlm of thls study wds to exdmlne the expression of TLR9 ln rendl cell cdrclnomd RCC whlch ls generally renowned of lts lmmunogenlc ndture. We dlso evdludted the prognostic vdlue of TLR9 ln RCC. Methods TLR9 expression ln RCC wds characterized with lmmunohlstochemlstry ln d retrospective study populdtlon of 152 RCC pdtlents who underwent rendl surgery. The TLR9 stdining intensity wds compdred with clinicdl pdrdmeters. Results Of the studled tumours 112 81 exhlblted cytopldsmlc TLR9 lmmunostdlnlng. No dssocldtlon wds detected between cytopldsmlc TLR9 lmmunoexpresslon intensity dnd stdge nucledr grade histologicdl subtype or tumour necrosls. Cytopldsmlc TLR9 lmmunoexpresslon wds however d mdrker of fdvourdble RCC specific survlvdl both ln unlvdrldte dndlysls dnd ln multlvdrldte regresslon model. Conclusions We conclude thdt TLR9 expression ls dn lndependent prognostic mdrker of RCC dnd the dbsence of TLR9 expression ls reldted to poorer prognosls ln RCC. Keywords rendl cell cdrcinomd toll-like receptor 9 tumour necrosis prognosis Background Renal cell carcinoma RCC is a cancer of increasing incidence and mortality 1 . At the time of the diagnosis up to one third of the patients have metastasized disease and a half of the remaining patients will experience a recurrence after an