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báo cáo khoa học: "Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report | Miguchi et al. World Journal of Surgical Oncology 2011 9 33 http www.wjso.eom content 9 1 33 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Malignant peripheral nerve sheath tumor arising from the greater omentum Case report Masashi Miguchi Yuji Takakura Hiroyuki Egi Takao Hinoi Tomohiro Adachi Yasuo Kawaguchi Manabu Shinomura Masakazu Tokunaga Masazumi Okajima Hideki Ohdan Abstract Malignant peripheral nerve sheath tumors MPNSTs are rare soft tissue tumors that arise from a peripheral nerve or exhibit nerve sheath differentiation. Most of these tumors arise on the trunk extremities or head and neck regions they are very rarely located in the abdominal cavity. The patient was a 71-year-old man who was referred to our hospital for a mass and pain in the right lower abdomen. Abdominal computed tomography revealed a large 9 X 9 cm well-circumscribed lobulated heterogeneously enhanced mass in the pelvis. Exploratory laparotomy revealed a large mass in the greater omentum and the tumor was completely excised. Histopathological analysis revealed that the tumor was composed of spindle cells with high mitotic activity. On staining the tumor positive results were obtained for S-100 but negative results were obtained for c-kit cluster of differentiation CD 34 a-smooth muscle actin and desmin. These findings strongly supported a diagnosis of MPNST primarily arising from the greater omentum. To the best of our knowledge this is the first reported case of an MPNST arising from the greater omentum. In this report we have described the case of a patient with an MPNST arising from the greater omentum and have discussed the clinical characteristics and management of MPNSTs. Background Primary solid omental tumors are rare and include various types of tumors such as gastrointestinal stromal tumors GIST leiomyosarcomas hemangiocytomas fibrosarcomas leiomyomas liposarcomas desmoids tumors fibromas mesotheliomas and myosarcomas 1 . Although the pathological spectrum of