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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"

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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis. | Int. J. Med. Sci. 2010 7 300 International Journal of Medical Sciences 2010 7 5 300-308 Ivyspring International Publisher. All rights reserved Research Paper Genetic polymorphism of p53 but not GSTP1 is association with susceptibility to esophageal cancer risk - A Meta-Analysis Yaping Zhao1 Furu Wang2 3 Shunlin Shan4 Yiqi Zhao5 Xueming Qiu6 Xiangyang Li4 Feng Jiao5 Jian-guo Wang4 x Yunxiang Du4 x 1. Department of Laboratory The 82th Hospital of the People s Liberation Army Huaian 223001 China 2. Department of Epidemiology and Biostatistics Cancer Center Nanjing Medical University Nanjing 210029 China 3. JiangSu Provincial Center for Disease Prevention and Control Nanjing 210009 China 4. Department of Oncology The 82th Hospital of the People s Liberation Army Huaian 223001 China 5. Department of Surgery The 82th Hospital of the People s Liberation Army Huaian 223001 China 6. Department of Gastroenterology The 82th Hospital of the People s Liberation Army Huaian 223001 China. These authors contributed equally to this work. H Corresponding author J. Wang Tel. 86-0517-8356-8701 Fax 86-0517-8377-1001 email hyxwd@sina.com. Y. Du Tel. 86-0517-8356-8701 Fax 86-0517-8377-1001 email duyunxiang82yy@yahoo.com.cn. Received 2010.07.25 Accepted 2010.08.31 Published 2010.09.01 Abstract A number of studies have evaluated two functional polymorphisms on p53 Arg72Pro and GSTPI Ile105Val in relation to esophageal cancer susceptibility. However the results remain conflicting rather than conclusive. This meta-analysis on 2919 cases and 4074 controls for p53 Arg72Pro and 1885 cases and 2194 controls for GSTPI Ile105Val from 13 published case-control studies showed that no significant general main effects for GSTPI Ile105Val on esophageal cancer risk. However we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer Pro Arg Pro Pro versus Arg Arg OR 1.20 95 CI 1.06- 1.36 without any between-study heterogeneity. In the stratified analysis by ethnicity we .

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