tailieunhanh - Báo cáo y học: "Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study. | García-Laorden et al. Critical Care 2011 15 R57 http content 15 1 R57 KS CRITICAL CARE RESEARCH Open Access Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia a prospective observational genetic study Ml I r z I r z fI fs ZZ J Z 1 c I I D fs z l z ír A I IZ 7 Z J Z r - r t r r 2 3 I fs ZZ J I c fs I zA ỉ z I A k 4 I z D-s I r 5 I z t A D I Z t I I M 6 Isabel Garcia-Laoraen Felipe Roariguez ae Castro Jorai Solé-violan Olga Rajas José Blanquer I I 11 r D Z S ZZ z ri r 7 Ar k -s 5 I I I I r -s Dri z z r 8 D z z l rr S c ZZ Z J 9 I Ạ I L- . h I v-f zs r- D s rn z r 10 Luis Boraerias Javier Aspa M Luisa Briones Pearo Saavedra J Alberto iviarcos-Ramos Nereida Gonzalez-Queveao1 Ithaisa Sologuren1 Estefania Herrera-Ramos1 José M Ferrer4 Jorai Rello11 Carlos Roariguez-Gallego1 3 Abstract Introduction Genetic variability of the pulmonary surfactant proteins A ana D may affect clearance of microorganisms ana the extent of the inflammatory response. The genes of these collectins SFTPA1 SFTPA2 ana SFTPD are locatea in a cluster at 10q21-24. The objective of this stuay was to evaluate the existence of linkage aisequilibrium LD among these genes ana the association of variability at these genes with susceptibility ana outcome of community-acquirea pneumonia CAP . We also stuaiea the effect of genetic variability on SP-D serum levels. Methods Seven non-synonymous polymorphisms of SFTPA1 SFTPA2 ana SFTPD were analyzea. For susceptibility 682 CAP patients ana 769 controls were stuaiea in a case-control stuay. Severity ana outcome were evaluatea in a prospective stuay. Haplotypes were inferrea ana LD was characterizea. SP-D serum levels were measurea in healthy controls. Results The SFTPD aa11-C allele was significantly associatea with lower SP-D serum levels in a aose-aepenaent manner. We observea the existence of LD among the stuaiea genes. Haplotypes SFTPA1 6A2 P oaas ration OR SFTPA2 1A0 P OR .