tailieunhanh - Báo cáo y học: "Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map. | Open Access Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense chromosomal segregation crossing over and the construction of a genetic map Anneli Cooper Andy Tait Lindsay Sweeney Alison Tweedie Liam Morrison C Michael R Turner and Annette MacLeod Addresses Wellcome Centre for Molecular Parasitology Glasgow Biomedical Research Centre University Place Glasgow G12 8TA UK. Division of Infection and Immunity Faculty of Biomedical and Life Sciences Glasgow Biomedical Research Centre University Place Glasgow G12 8TA UK. Correspondence Anneli Cooper. Email acc15p@ Published 22 June 2008 Genome Biology 2008 9 R103 doi gb-2008-9-6-rl03 The electronic version of this article is the complete one and can be found online at http 2008 9 6 R103 Received 8 February 2008 Revised 20 May 2008 Accepted 22 June 2008 2008 Cooper et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Trypanosoma brucei is the causative agent of human sleeping sickness and animal trypanosomiasis in sub-Saharan Africa and it has been subdivided into three subspecies Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense which cause sleeping sickness in humans and the nonhuman infective Trypanosoma brucei brucei. T. b. gambiense is the most clinically relevant subspecies being responsible for more than 90 of all trypanosomal disease in humans. The genome sequence is now available and a Mendelian genetic system has been demonstrated in T. brucei facilitating genetic analysis in this diploid protozoan parasite. As an essential step toward identifying loci that determine important traits in the human-infective subspecies we report the construction of a high-resolution .