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Báo cáo y học: " A cell surface interaction network of neural leucine-rich repeat receptor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: A cell surface interaction network of neural leucine-rich repeat receptors. | Open Access Reseprc h A cell surface interaction network of neural leucine-rich repeat receptors Christian Sõllner ỷ and Gavin J Wright Addresses Cell Surface Signalling Laboratory Wellcome Trust Sanger Institute Hinxton Cambridge CB10 1HH UK. Current address Max Planck Institute for Developmental Biology Department 3 Genetics Spemannstrabe 35 72076 Tubingen Germany. Correspondence Christian Sõllner. Email christian.soellner@tuebingen.mpg.de. Gavin J Wright. Email gw2@sanger.ac.uk Published 18 September 2009 Genome Biology 2009 10 R99 doi 10.1186 gb-2009- 10-9-r99 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 9 R99 Received 9 June 2009 Revised 18 August 2009 Accepted 18 September 2009 2009 Sollner and Wright licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The vast number of precise intercellular connections within vertebrate nervous systems is only partly explained by the comparatively few known extracellular guidance cues. Large families of neural orphan receptor proteins have been identified and are likely to contribute to these recognition processes but due to the technical difficulty in identifying novel extracellular interactions of membrane-embedded proteins their ligands remain unknown. Results To identify novel neural recognition signals we performed a large systematic protein interaction screen using an assay capable of detecting low affinity extracellular protein interactions between the ectodomains of 150 zebrafish receptor proteins containing leucine-rich-repeat and or immunoglobulin superfamily domains. We screened 7 592 interactions to construct a network of 34 cell surface receptor-ligand pairs that included orphan .