tailieunhanh - Báo cáo y học: "Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy. | Retrovirology BioMed Central Open Access Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV individuals on highly active antiretroviral therapy Jing Qin Wu1 Wayne B Dyer2 Jeremy Chrisp3 Larissa Belov3 Bin Wang1 and Nitin K Saksena 1 Address Retroviral Genetics Division Center for Virus Research Westmead Millennium Institute University of Sydney Darcy Road Westmead NSW 2145 Sydney Australia 2Immunovirology Laboratory Australian Red Cross Blood Service Clarence Street Sydney NSW 2000 Australia and 3Medsaic Pty Ltd Suite 145 National Innovation Centre Australian Technology Park Garden Street Eveleigh NSW 1430 Sydney Australia Email Jing Qin Wu - jingqin_wu@ Wayne B Dyer - WDyer@ Jeremy Chrisp - Larissa Belov - Bin Wang - bin_wang@ Nitin K Saksena - nitin_saksena@ Corresponding author Published 4 March 2008 Received 29 November 2007 Accepted 4 March 2008 Retrovirology 2008 5 24 doi l 742-4690-5-24 p This article is available from http content 5 1 24 2008 Wu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The efficacy of highly active antiretroviral therapy HAART determined by simultaneous monitoring over 100 cell-surface antigens overtime has not been attempted. We used an antibody microarray to analyze changes in the expression of 135 different cell-surface antigens overtime on PBMC from HIV patients on HAART. Two groups were chosen one n 6 achieved sustainable response by maintaining below detectable plasma .