tailieunhanh - Báo cáo y học: "The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane α"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane αβ . | Protein family review The integrins Yoshikazu Takada Xiaojing Ye and Scott Simon Addresses Department of Dermatology University of California Davis School of Medicine Second Avenue Sacramento CA 95817 USA. Department of Biomedical Engineering College of Engineering University of California East Health Sciences Drive Davis CA 95616 USA. Correspondence Yoshikazu Takada. Email ytakada@ Published I June 2007 Genome Biology 2007 8 2I5 doi gb-2007-8-5-2I5 The electronic version of this article is the complete one and can be found online at http 2007 8 5 2I5 2007 BioMed Central Ltd Summary The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands cell-surface ligands and soluble ligands. They are transmembrane ap heterodimers and at least I8 a and eight p subunits are known in humans generating 24 heterodimers. Members of this family have been found in mammals chicken and zebrafish as well as lower eukaryotes including sponges the nematode Caenorhabditis elegans two a and one p subunits generating two integrins and the fruitfly Drosophila melanogaster five a and one p generating five integrins . The a and p subunits have distinct domain structures with extracellular domains from each subunit contributing to the ligand-binding site of the heterodimer. The sequence arginine-glycine-aspartic acid RGD was identified as a general integrin-binding motif but individual integrins are also specific for particular protein ligands. Immunologically important integrin ligands are the intercellular adhesion molecules ICAMs immunoglobulin superfamily members present on inflamed endothelium and antigen-presenting cells. On ligand binding integrins transduce signals into the cell interior they can also receive intracellular signals that regulate their ligand-binding affinity. Here we provide a brief overview that concentrates mostly on the organization structure and function of mammalian integrins which have .