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Báo cáo y học: " Divergence of exonic splicing elements after gene duplication and the impact on gene structures"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Divergence of exonic splicing elements after gene duplication and the impact on gene structures. | Open Access Researc h Divergence of exonic splicing elements after gene duplication and the impact on gene structures Zhenguo ZhangH Li ZhouH Ping Wang Yang Liu Xianfeng Chen Landian Hu and Xiangyin Kong Addresses The Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes for Biological Sciences SIBS Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM 225 South Chong Qing Road Shanghai 200025 PR China. Graduate School of the Chinese Academy of Sciences 19A Yuquan Road Beijing 100049 PR China. State Key Laboratory of Medical Genomics Ruijin Hospital Shanghai Jiaotong University 197 Rui Jin Road II Shanghai 200025 PR China. n These authors contributed equally to this work. Correspondence Xiangyin Kong. Email xykong@sibs.ac.cn Published 2 November 2009 Genome Biology 2009 10 RI20 doi 10.1186 gb-2009-I0-II-rI 20 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 11 R120 Received 15 June 2009 Revised 28 September 2009 Accepted 2 November 2009 2009 Zhang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The origin of new genes and their contribution to functional novelty has been the subject of considerable interest. There has been much progress in understanding the mechanisms by which new genes originate. Here we examine a novel way that new gene structures could originate namely through the evolution of new alternative splicing isoforms after gene duplication. Results We studied the divergence of exonic splicing enhancers and silencers after gene duplication and the contributions of such divergence to the generation of new splicing isoforms. We found that exonic .